ICON8: Weekly Chemotherapy in Ovarian Cancer

Inclusion Criteria: * Females aged 18 years or more * Signed informed consent and ability to comply with the protocol * Histologically confirmed, with core biopsy from a disease site as minimum requirement (cytology alone is insufficient for diagnosis): * Epithelial ovarian carcinoma * Primary peritoneal carcinoma of Müllerian histological type * Fallopian tube carcinoma * FIGO stage IC or above, which may be based on clinical and radiological assessment in patients who have not undergone immediate primary surgery * Confirmed high-risk histological subtype for patients with FIGO stage IC/IIA disease, namely: * High grade serous carcinoma * Clear cell carcinoma * Other histological subtype considered poorly differentiated/grade 3 * ECOG Performance Status (PS) 0-2 * Life expectancy \> 12 weeks * Adequate bone marrow function: * Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/l * Platelets (Plt) ≥ 100 x 109/l * Haemoglobin (Hb) ≥ 9g/dl (can be post transfusion) * Adequate liver function (within 28 days prior to randomisation): * Serum bilirubin (BR) ≤ 1.5 x ULN * Serum transaminases ≤ 3 x ULN in the absence of parenchymal liver metastases or ≤ 5 x ULN in the presence of parenchymal liver metastases * Adequate renal function as defined by GFR (Glomerular Filtration Rate) ≥ 30ml/min. Exclusion Criteria: * Non-epithelial ovarian cancer, including malignant mixed Müllerian tumours (carcinosarcomas) * Peritoneal cancer that is not of Müllerian origin, including mucinous histology * Borderline tumours (tumours of low malignant potential) * Prior systemic anti-cancer therapy for ovarian cancer (for example chemotherapy, monoclonal antibody therapy, tyrosine kinase inhibitor therapy or hormonal therapy) * Previous malignancies within 5 years prior to randomisation apart from: adequately treated carcinoma in-situ of the cervix, breast ductal carcinoma in-situ, non-melanomatous skin cancer; or previous/synchronous early-stage endometrial cancer defined as stage IA (FIGO 2009) grade 1 or 2 endometrioid cancers with no lymphovascular space invasion * Pre-existing sensory or motor neuropathy grade ≥ 2 * Evidence of any other disease/metabolic dysfunction that in the opinion of the investigator would put the subject at high-risk of treatment-related complications or prevent compliance with the trial protocol * Planned intraperitoneal cytotoxic chemotherapy * Any previous radiotherapy to the abdomen or pelvis * Sexually active women of childbearing potential not willing to use adequate contraception (e.g. oral contraceptives, intrauterine device or barrier method of contraception in conjunction with spermicidal jelly or surgically sterile) for the study duration and at least six months afterwards * Pregnant or lactating women * Treatment with any other investigational agent prior to protocol defined progression * Known hypersensitivity to carboplatin, paclitaxel or their excipients (including cremophor) * History or clinical suspicion of brain metastases or spinal cord compression. CT/MRI of the brain is mandatory in the case of suspected brain metastases. Spinal MRI is mandatory in the case of suspected spinal cord compression. Patients with brain or meningeal metastases are not eligible