Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke

Chang Gung Memorial Hospital2 enrolled

Overview

The purpose of this study will evaluate the long-term benefits, optimal dose and mechanisms of mirror therapy and its effects on physiological markers.

This trial is to examine whether (1) the immediate effects of treatment intensity in MT would occur on sensorimotor impairments and functional performance in patients with subacute stroke; (2) the long-term benefits of treatment intensity in MT on functionality can persist for six months after treatment finished; and (3) the MT could result in cortical/movement reorganization as well as the changes in physiological markers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Cerebrovascular Accident

Interventions

MT with low-intensity group (MT-LI)BEHAVIORAL

The MT-LI group will receive a 30-minute MT per session followed by a 30-minute functional training.

MT with moderate-intensity groupBEHAVIORAL

The MT-MI group will receive a 60-minute MT per session followed by a 30-minute functional training.

Mirror therapy with high intensity groupBEHAVIORAL

The MT-HI group will receive a 90-minute MT per session followed by a 30-minute functional training

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * first episode of stroke in cortical regions * time since stroke less than 3 months * initial motor part of UE of FMA score ranging from 24 to 52 * no serious cognitive impairment Exclusion Criteria: * aphasia * visual impairments * major health problems or poor physical conditions * currently participation in any other

Locations (1)

Chang Gung Memorial Hospital

Kwei-shan, Toayuan County, Taiwan

Outcomes

Primary Outcomes

Fugl-Meyer Assessment (FMA)

The UE subscale of the FMA (max. score 66) uses a 3-point ordinal scale to assess motor impairment.

Time frame: Baseline, change from baseline in FMA at 2 weeks, and change from baseline in FMA at 4 weeks

Action Research Arm Test (ARAT)

ARAT will be used to assess the motor function of UE. A total of 19 items are to test the movement of grasp, grip, pinch, and gross motor, with a scale of 0-3 for each item (maximal of 57).

Time frame: Baseline, change of ARAT at 2 weeks, and change of ARAT at 4 weeks

Motor Activity Log (MAL)

The MAL is a semi-structured interview of patients to assess the amount of use (AOU) and quality of movement (QOM) of the affected upper extremity in 30 important daily activities using a 6-point ordinal scale. Higher scores indicate better performance.

Time frame: Baseline, change of MAL at 2 weeks, and change of MAL at 4 weeks

ABILHAND Questionnaire

ABILHAND questionnaire is an inventory of 56 manual activities that uses a 3-point ordinal scale to measure subjectively perceived difficulty in performing everyday bimanual activity.

Time frame: Baseline, change of ABILHAND Questionnaire at 2 weeks, and change of ABILHAND Questionnaire at 4 weeks

Adelaide Activities Profile (AAP)

AAP will be applied to indicate the level of participation in household and community activities. This profile includes 21 activities in the four areas: domestic chores, household maintenance, service to others, and social activities.

Time frame: Baseline, change of AAP at 2 weeks, and change of AAP at 4 weeks

Secondary Outcomes

Functional magnetic resonance imaging (fMRI)

Data from ClinicalTrials.gov

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