This is a safety and efficacy study evaluating a experimental treatment for cognitive deficits in adults with schizophrenia.
This is a Phase 2 study designed to evaluate the safety and efficacy of ABT-126 in treating cognitive deficits in subjects with a diagnosis of schizophrenia. Eligible subjects will take study drug as an add-on treatment to their ongoing antipsychotic treatment regimen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
432
Cognition: MCCB (MATRICS Consensus Cognitive Battery)
Rater based interview
Time frame: Change from baseline to week 24
Functioning: UPSA-2 (University of California San Diego Performance-based Skills Assessment-2)
Rater based interview
Time frame: Measurements from screening period up through week 24
Symptom Severity: PANSS (Positive and Negative Symptom Scale)
Rater based interview
Time frame: Measurements from screening period up through week 24
Symptom Severity: NSA-16 (16-item version of the Negative Symptom Assessment Scale)
Rater based interview
Time frame: Measurements from screening period up through week 24
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Placebo
Site Reference ID/Investigator# 75139
Anaheim, California, United States
Site Reference ID/Investigator# 74894
Bellflower, California, United States
Site Reference ID/Investigator# 74434
Chino, California, United States
Site Reference ID/Investigator# 76593
Costa Mesa, California, United States
Site Reference ID/Investigator# 73213
Escondido, California, United States
Site Reference ID/Investigator# 72698
Garden Grove, California, United States
Site Reference ID/Investigator# 75057
La Habra, California, United States
Site Reference ID/Investigator# 72693
National City, California, United States
Site Reference ID/Investigator# 77655
Norwalk, California, United States
Site Reference ID/Investigator# 74895
Oakland, California, United States
...and 51 more locations