By enabling a partial rebreathing of expired gas, a moderate respiratory acidosis is induced, without causing hypoxia in the patient. Based on the scientific literature on the subject, the study hypothesis is that the fall in body pH will be able to stop and/or prevent epileptic brain activity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
10
The CDA (Carbon Dioxide Accumulation) mask effectuates an increase in the inspired CO2 fraction, while allowing an adequate supply of fresh air to the patient.
The dummy mask is similar in appearance to the treatment mask, but causes only a negligible change in blood gases
Aarhus University Hospital
Aarhus, Denmark
The Epilepsy Hospital Filadelfia
Dianalund, Denmark
Length of epileptic seizure (subgroup 1)
Length of epileptic seizure with treatment mask vs. dummy mask
Time frame: Duration of mask treatment during acute seizures: approx. 3 minutes from start of mask treatment until end of seizure
Frequency of epileptic paroxysms (subgroups 2 and 3)
Frequency of epileptic paroxysms as measured by EEG, treatment mask vs. dummy mask
Time frame: Duration of mask treatment: 45 minutes (group 2) or 10 minutes (group 3) during which patient is monitored with EEG
Oxygen saturation during mask treatment
Measures oxygen saturation using a pulse oximeter during mask treatment
Time frame: Duration of mask treatment
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