P. Gingivalis IgG Titer Test for Periodontitis

Okayama University1,387 enrolled

Overview

This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.

Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.

Study Type

OBSERVATIONAL

Enrollment

1,387

Conditions

Periodontitis

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * periodontal patients * adults Exclusion Criteria: * difficulty of communication * received periodontal therapy within 3 months * with other diseases, i.e., hypertension, diabetes (self reported)

Locations (12)

Aichi Gakuin University, School of Dentistry

Nagoya, Aichi-ken, Japan

Toyota Motor Corporation

Toyota, Aichi-ken, Japan

Nihon University School of Dentistry at Matsudo

Matsudo, Chiba, Japan

Outcomes

Primary Outcomes

Level of IgG antibodies in serum/plasma against periodontal pathogens

Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "ELISA" method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis

Time frame: 1 to 3 months after basic periodontal treatment (Scaling and root planing)

Secondary Outcomes

Periodontal pocket depth

Clinical observation on periodontal pocket depth before and after basic periodontal treatment, in order to confirm appropriate effects of the treatment.

Time frame: 1 to 3 months after basic periodontal treatment

Bleeding on probing

Judging from bleeding from gingiva after periodontal pocket probing, degree of inflammation will be understood.

Time frame: 1 to 3 monthsafter basic periodontal treatment

Tooth mobility

Clinical observation to understand decrease of inflammation

Time frame: 1 to 3 months after basic periodontal treatment

Data from ClinicalTrials.gov

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