Drug Eluting Balloon (DEB) and Long Lesions of Superficial Femoral Artery (SFA) Ischemic Vascular Disease

Inclusion Criteria: * Documented ischemic, symptomatic arterial disease in the femoral-popliteal arteries according to Rutherford Category 2, 3 or 4; * Target lesion consists of a single solitary or multiple adjacent de novo or restenotic lesions (non-in-stent) with diameter stenosis ≥ 70% by visual estimate and cumulative lesion length ≥ 15 cm; * Target vessel is the superficial femoral artery and/or proximal popliteal artery (above the knee); * Life expectancy \>1 year in the Investigator's opinion; * Written informed consent. Exclusion criteria: Given the observational nature of the study, no study-specific but only clinical exclusion criteria will apply: * Patient unwilling or unlikely to comply with FU schedule; * Administration of local or systemic thrombolytic therapy within 48 hours prior to the index procedure; * Known allergies or sensitivities to heparin, aspirin, other anticoagulant/antiplatelet therapies, and/or paclitaxel; * Additional planned cardiac or peripheral percutaneous or surgical intervention including CABG within 30 days following the study procedure; * 15 cm long inflow lesion (≥50% DS) or occlusion (any length) in the ipsilateral Iliac artery; * Failure to successfully treat \< 15 cm long inflow lesion in the ipsilateral Iliac artery