Every patient with HCC (Hepato-Cellular Carcinoma) with main portal vein thrombosis will be screened for presence of large esophageal varices and will be randomized between non-selective beta blocker versus primary endoscopic variceal ligation. They will be followed to assess the rate of reduction of index bleed rate as well as survival difference between the groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Endoscopic Variceal Ligation every 3 weeks till eradication.
Carvedilol 3.125mg BD increased after 1 week to reach 6.25mg BD
Institute of Liver and Biliary Sciences
New Delhi, National Capital Territory of Delhi, India
First Variceal Bleeding
Time frame: 1.5 years
Death
Time frame: 1.5 years
Procedure related complications.
Time frame: 1.5 years
Reappearance of Esophageal varices in presence of Portal Vein Thrombosis
Time frame: 1.5 years
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