Enhanced External Counterpulsation and Its Effects on Vascular Hemodynamics in Cognitively Impaired Patients

Inclusion Criteria: * An adult between 18 and 85 years of age. * Has been evaluated to have a CDR (Clinical Dementia Rating) Score of 0.5 * Male or female (if female must be postmenopausal for at least 1 year, surgically sterile or using an effective form of contraception). * Able to speak and read English. * Willing to comply with study specific instructions, and complete all study procedures according to protocol. * Able to understand study rationale and sign informed consent. Exclusion Criteria: * Diagnosed with glaucoma * History of developing adverse effects to ophthalmic dilating agents (phenylephrine or tropicamide). * Currently taking warfarin and dabigatran (Pradaxa). * History of having arrhythmias - can interfere with EECP triggering. * Subject has bleeding diathesis. * Subject has active thrombophlebitis. * Subject has severe lower extremity vaso-occlusive disease. * Subject has a documented aortic aneurysm requiring surgical repair. * Subject is pregnant. * Subject with blood pressure higher than 180/110 mmHg. * Subject with a heart rate more than 120 bpm. * Subject with high risk of complications from increased venous return. * Subject with clinically significant valvular disease. * Subjects with severe vascular disease as established by the Hachinski Ischemic Index. * Subjects with pacemakers and other metallic implantable devices.