Safety Tolerability & Pharmacokinetics of Co-administered Single Doses of OZ439 & Piperaquine to Healthy Subjects

Inclusion Criteria: * Healthy males \& females, 18-55 years old * BMI 18 to 30kg/m2; total body weight \>50kg * Healthy, determined by pre-study medical history, physical examination vital signs, 12 Lead ECG * Females of non-childbearing potential. * Males must agree to use a double barrier method of contraception * Lab tests at screening within the reference ranges Exclusion Criteria: * Any condition that could affect drug absorption, e.g. gastrectomy, diarrhea * Clinically relevant abnormalities in ECG * Family history of sudden death or of congenital prolongation of QTc interval - History of symptomatic cardiac arrhythmias or with clinically relevant bradycardia * Electrolyte disturbances * History of drug or alcohol abuse, tobacco users * Participation in evaluation of any drug for 3 months before the study * Administration of ANY systemic medication/herbal product within 14 days of first dose of study drug. * unaccustomed strenuous exercise within 7 days of any study visit * Alcohol consumption within 24 hours of any study visit * Consumption of any fruit juice or food containing grapefruit within 7 days * Positive test for HIV-1, HBsAg or HCV * Positive urine drug screen at Screening or admission * Severe allergies/multiple drug allergies * Volunteers who have donated blood or experienced significant blood loss within 90 days of screening * Hemoglobin below lower limit of the reference range * Clinically relevant abnormal lab values indicative of physical illness