Exercise Test and Cardiac Injury

Radboud University Medical Center20 enrolled

Overview

Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply that mimic those of ischemia and reperfusion injury. If the mechanism underlying the troponin release during exercise is similar to that of ischemia reperfusion injury (IRI), than it should be susceptible to remote ischemic preconditioning (RIPC) as RIPC is a well validated technique to reduce IRI. To test this hypothesis healthy volunteers underwent a strenuous exercise test with or without preceding RIPC.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cardiovascular Disease

Interventions

remote ischemic preconditioning (RIPC)OTHER

RIPC protocol which consist of three 5-min cycles of bilateral forearm ischemia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age: 18-45 year * willing to sign informed consent * healthy Exclusion Criteria: * hypertension (systolic blood pressure \>140 mmHg or diastolic blood pressure \> 90 mmHg) * any cardiovascular abnormality in past medical history, physical examination or ECG, including QTc interval * drug abuse * alcohol abuse (\> 3 units/day) * smoking during the last 2 years * BMI \>30 kg/m2 * inability to perform bicycle test * the presence of an absolute or relative contra-indication for exercise (table 2 in protocol) * the presence of diabetes (fasting glucose \> 6.9 mmol/L, non-fasting glucose \>11.0 mmol/L; if non-fasting glucose is \> 6.9 mmol/L, blood glucose measurement will be repeated in fasting condition and should then not exceed 6.9 mmol/L) * total cholesterol in blood 6.6 mmol/L or higher

Locations (1)

Radboud University Nijmegen Medical Centre

Nijmegen, Netherlands

Outcomes

Primary Outcomes

serum level of high sensitive troponin at several timepoints

serum level of high sensitive troponin in response to intensive exercise test with or without RIPC at several timepoints

Time frame: timepoints t= baseline, 0, 1, 2, 3,4 and 8 hours after finishing exercise

Data from ClinicalTrials.gov

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