* To estimate dopamine receptor occupancy by aripiprazole using computer simulation * To measure dopamine receptor occupancy by aripiprazole in patients treated with the antipsychotics * To validate the simulation result by comparing the receptor occupancy from the simulation with that from the patients
Study Type
OBSERVATIONAL
Enrollment
7
Seoul National University Hospital
Seoul, South Korea
Dopamine receptor occupancy
Measured using 11C-raclopride positron emission tomography
Time frame: 72 hrs after the last administration
Hamilton rating scale for depression
HAM-D score
Time frame: Baseline and 72 hours after the last administration
Barnes akathisia scale
BAS score
Time frame: Baseline and 72 hours after the last administration
Abnormal involuntary movement scale
AIMS score
Time frame: Baseline and 72 hours after the last administration
Simpson-Angus scale
SAS score
Time frame: Baseline and 72 hours after the last administration
Treatment satisfaction questionnaire for medication
TSQM score
Time frame: Baseline and 72 hours after the last administration
Medication satisfaction questionnaire
MSQ score
Time frame: Baseline and 72 hours after the last administration
N-back task
To measure the change in working memory performance
Time frame: Baseline and 72 hours after the last administration
Prolactin level
To explore the effect of receptor occupancy on the blood prolactin level
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Time frame: Baseline and 72 hours after the last administration
Dopamine receptor occupancy
Time frame: 3 hrs after the last administration
Dopamine receptor occupancy
Time frame: 24 hrs after the last administration