A Study of Neoadjuvant FOLFIRINOX and FDR-Gemcitabine With Concurrent IMRT in Patients

Inclusion Criteria: * Patients must have cytologic or histologic confirmation of carcinoma arising in the pancreas. * Patients must be deemed to have borderline resectable disease with no radiologic evidence of distant metastatic disease prior to registration. * Specifically, patients must have at least one designation of borderline resectable and no designation of unresectable disease. * Patients must have a life expectancy of at least 12 weeks, a Zubrod performance status of \< 1 and be willing and medically able to undergo surgical resection. * Patients must have adequate organ function defined as follows: absolute neutrophil count of \> 1500/mm3, platelets \> 100,000/mm3, serum Cr \< 1.5 mg/dl, total bilirubin \< 2.0 mg/dl with relief of biliary obstruction if present (PTC tube or endobiliary stent). * Patients must be free of other active systemic malignancy, ongoing infection, or any other serious uncontrolled, concomitant systemic disorders or psychiatric condition that would interfere with the safe delivery of protocol therapy. * Patients of reproductive potential must agree to use an effective contraceptive method during participation in this trial due to the unacceptable teratogenic toxicity of abdominal radiation and cytotoxic chemotherapy. * Patients must be aware of the investigational nature of the therapy and provide written informed consent. Exclusion Criteria: * Patients with neuroendocrine tumors are excluded. * Active systemic malignancy, ongoing infection, or any other serious uncontrolled, concomitant systemic disorders or psychiatric condition that would interfere with the safe delivery of protocol therapy. * Patients with preexisting peripheral neuropathy \> grade 2 are ineligible * Pregnant or nursing women are ineligible. * Patients must have no history of previous chemotherapy for pancreatic cancer or any abdominal radiation therapy. * Patients may not have used any investigational agent within 4 weeks prior to enrollment into the study.