The Effect of Humidification on Mucus Rheology

Virginia Commonwealth University18 enrolled

Overview

In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease(COPD)

Eligibility

Sex: ALLMin age: 40 YearsMax age: 90 Years

Medical Language ↔ Plain English

Mechanically Ventilated Patients Inclusion Criteria: Any Subject Mechanically Ventilated and producing sputum. Exclusion * None COPD Group Inclusion Criteria: * 40 to 90 years of age suffering from COPD * History of mucus production Exclusion Criteria: * None

Locations (1)

Virginia Commonwealth University

Richmond, Virginia, United States

Outcomes

Primary Outcomes

Sputum Collection

Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.

Time frame: 10 minutes

Data from ClinicalTrials.gov

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