Predicting Ovarian Response in Artificial Insemination With Low Stimulation

Inclusion Criteria: * couples with unexplained or mild male subfertility (1-3) and a spontaneous chance of conception below 40% (Hunault score). * Unexplained subfertility including minimal to mild endometriosis (AFS grade 1 or 2) is defined as the failure to conceive after at least one year of unprotected intercourse whereas the standard fertility work-up was unable to detect any factors that might influence fertility negatively. * semen analysis should be normal according to the WHO guidelines (8), * ovulation should be documented (by BBT charts, ovulation detection by ultrasound or normal luteal progesterone values), * tubal patency should be confirmed (HSG, laparoscopy or fertiloscopy) and when a postcoital test was performed a cervical factor should have been excluded. * Mild male subfertility is defined as abnormal semen parameters according to the WHO (8) but an average total motile sperm account before processing of at least 10 million. Exclusion Criteria: * Hunault score ≥ 40% * Endometriosis AFS grade 3 or 4 * Contra-indications for the use of gonadotrophins (cysts larger than 2 cm, allergy for gonadotrophins) * Total motile sperm count after sperm processing below 1 million * Women aged younger than eighteen years or older than 45 years. * Previous treatment with COH/IUI for treating current subfertility * Unable to speak or read the Dutch language