Interleukin-1 Trap to Treat Vascular Dysfunction in Chronic Kidney Disease (CKD)

Inclusion Criteria: * Age 18-80 years * CKD stage III or IV (eGFR with the 4-variable Modified Diet Renal Disease (MDRD) prediction equation: 15-60 mL/min/1.73m2; stable renal function in the past 3 months) * An elevated high sensitivity C-reactive protein (hs-CRP) of \> 2.0 mg/L and \<30 mg/L on at least 2 consecutive weekly determinations * Urine protein excretion \< 5.0 g/24h estimated by a spot urine protein/creatinine ratio * Ability to provide informed consent Exclusion Criteria: * Patients with advanced CKD requiring chronic dialysis * Active infection (chronic or acute (within 3 months) or antibiotic therapy (w/in 1 mo); history of recurrent infection * Significant co-morbid conditions that lead the investigator to conclude that life expectancy is less than 1 year * Expected to undergo living related transplant in next 6 months * History of severe congestive heart failure (i.e., EF \< 35%) * Hospitalization in the past month * Severe arthritis, lupus, inflammatory bowel disease, asthma or other disease(s) or medical condition(s) that, in the opinion of the investigator, could interfere with hsCRP or immune function * Immunosuppressant agents such as cyclosporine, tacrolimus, azathioprine, etanercept, infliximab, adalimumab, anakinra or long-term oral glucocorticoids taken in past 12 months * Known malignancy * HIV, active, chronic hepatitis B as evidenced by HBsAg positive and HBsAb negative, or hepatitis C positive * Woman who are pregnant, nursing or planning to become pregnant * Body mass index (BMI) \>40 kg/m2 * Warfarin use (or other cytochrome P (CYP)450 substrates with a narrow therapeutic index) \[ok if do not participate in endothelial cell collection\] * Taking medication(s) that interact with agents administered during experimental sessions (e.g., sildenafil interacts with nitroglycerin) * Currently receiving or planning to receive live or inactivated vaccines * Alcohol dependence or abuse * Subjects at risk for tuberculosis (TB). Specifically, subjects with: * Current clinical, radiographic or laboratory evidence of active TB at screening or latent TB that has not been previously treated * A history of active TB within the last 3 years even if it was treated. * A history of active TB greater than 3 years ago unless there is documentation that the prior anti-TB treatment was appropriate in duration and type. * Therapy for latent TB which has not been completed as per local guidelines.