Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cells Implantation in Patients With Critical Limb Ischemia

Inclusion Criteria: * At least 6 months since the onset CLI(Chronic ASO or Buerger disease) * Patients with luminal stenosis \> 50% by leg angiography * Age is between 20 and 80 * Patients whose Rutherford's class is II-4, III-5 or III-6 (Patients with rest pain or ischemic ulcer/necrosis) * Patients for whom angioplasty and bypass surgery are not indicated because of anatomical or procedural reasons or frequent reocclusion/restenosis following traditional revascularization * Patients who can give informed consent themselves in writing Exclusion Criteria: * Previous or current history of neoplasm or comorbidity that could impact the patient's survival * Detection of proximal source of emboli including atrial fibrillation * Primary hematologic disease, including hypercoagulable states * Detection of proliferative retinopathy * Entrapment syndrome * Alcohol abuse, cocaine amphetamine etc. * Detection of osteomyelitis * Uncontrolled DM