Croup is common illness presenting emergency department with dyspnea. The main treatment for croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized L-epinephrine is restricted that the study of comparision between racemic epinephrine and L-epinephrine. The investigators conducted this study to compare the effectiveness of low dose L-epinephrine with conventional dose L-epinephrine.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
84
conventional dose epinephrine : 0.5mg/kg + 0.9% normal saline
low dose epineprhine : 0.1mg/kg + 0.9% normal saline
Seoul National University Hospital
Seoul, South Korea
RECRUITINGthe difference of Westley croup score between baseline and 30 minutes after neublized treatment
Time frame: 30 minutes
the incidence of use of additional neublized treatment
Time frame: 30 minutes
Westley croup score
Time frame: 30, 60, 90, 120, 180, 240 minutes
the side effect of epinephrine
Hypertension, tachycardia : more than 95th percentile for age Arrythmia Pallor Tremor
Time frame: participants will be followed for the duration of ED stay
respiratory rate, oxygen saturation
Time frame: 30, 60, 90, 120, 180, 240 minutes
health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom
Time frame: within 7 days
treatment failure
after additional nebulized epineprhine at 30 minutes, as the croup scrore is higher than baselin, the blinding is cleared.
Time frame: 30min after 2nd epinephrine nebulizer
rebound effect
the croup score is the same or over than the base line
Time frame: 180 minutes
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