Effects of Liraglutide on Kidney Function in Type 2 Diabetic Patients

Inclusion Criteria: * Informed consent obtained before any trial-related activities. * Male gender * T2DM, diagnosed according to international guidelines * Age 20-60 years, both included * Body Mass Index (BMI): 20-32 kg/m2, both included * Metformin treatment * Albumin/creatinine ratio \<25 mg/mmol Exclusion Criteria: * Known or suspected allergy to trial product or related products * Previous participation in this trial * Previous treatment with GLP-1 analogues or DPP-4 inhibitors * Current treatment with any antidiabetic drug other than metformin * Poorly regulated glycemic control (HbA1c \> 8%) * Impaired kidney function: estimated GFR \< 70ml/min * Impaired liver function: liver parameters exceed 2 times upper normal limit * Subjects with active malignancy * Severe cardiac insufficiency classified according to NYHA III-IV * Unstable angina pectoris, acute myocardial infarction (AMI) within the last 12 months * Severe, uncontrolled hypertension: sitting blood pressure (BP) \> 180/110 mmHg * Antihypertensive treatment consisting of more than two different pharmaceutical products * Symptoms related to benign prostate hyperplasia * Claustrophobia * Any metal body implants * History of pancreatitis, type 1 diabetes, gastroparesis or multiple endocrine neoplasia syndrome type 2 * Personal or family history of medullary thyroid carcinoma * Any diseases judged by the investigator that could affect the trial * Any medication judged by the investigator that could affect the trial