Correlation study about Blood Pressure Variability and the prognosis of ischemic stroke with intracranial artery stenosis
Extracranial atherosclerotic stenosis is the main reason for the European and American white ischemic stroke and transient ischemic attack,while Atherosclerotic intracranial arterial stenosis is an important reason for Asian patients with stroke ,accounting for the 33% to 51% of a etiology ratio.The latest research suggests that varying degrees of blood pressure variability can affect the risk of stroke.This study observe the relationship between blood pressure variability and prognosis of ischemic stroke patients with intracranial arterial stenosis,with cranial magnetic resonance imaging (MRI + DWI),magnetic resonance angiography and Trans-cranial Doppler(TCD) .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
The amlodipine - based antihypertensive treatment group (you can add a diuretic or other )
ACEI / ARB -based antihypertensive treatment group ( you can add the B - blockers or other)
aspirin 100mg / d or Clopidogrel 75mg / d (anti-platelet agents)
RenJi Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGthe incidence of stroke in a follow-up period
Time frame: one year
blood pressure during the compliance status in a follow-up
Time frame: one year
patients with blood pressure variability in a follow-up
Time frame: one year
Changes in intracranial arterial stenosis and stiffness before and after the follow-up
Time frame: one year
Other vascular events ( acute ischemic heart disease or vascular death )
Time frame: one year
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Atorvastatin 10 - 40mg / d ( statin therapy)