STA-9090 in Patients With Advanced Hepatocellular Cancer

Inclusion Criteria: * Histologically or cytologically confirmed hepatocellular carcinoma * Measurable disease * Life expectancy greater than 3 months * ECOG performance status 0 or 1 * BCLC Stage C disease * Lab values must be within limits outlined in protocol * Child-Pugh score \</= 6 * CLIP score 0-3 * Must agree to use adequate contraception Exclusion Criteria: * Chemotherapy or radiotherapy within 4 weeks prior to entering study or not recovered from adverse events due to agents administered more than 4 weeks earlier * Receiving any other investigational agent * Known brain metastases unless treated and radiographically and clinically stable without steroid or anticonvulsant medications for at least 4 weeks prior to first dose of STA-9090 * History of allergic reactions attributed to compounds of similar chemical or biologic composition to STA-9090 * Surgery, radiotherapy, or lesion ablative procedure to the only area of measurable disease * Major surgery within 4 weeks prior to first dose of STA-9090 * Poor venous access for study drug administration or would require a peripheral or central indwelling catheter for study drug administration * History of severe allergic or hypersensitivity reactions to excipients (e.g., Polyethylene glycol \[PE\] 300 and Polysorbate 80) * Baseline QTc \> 450 msec or previous history of QT prolongation while taking other medications * Ventricular ejection fraction \</= 55% at baseline * Treatment with chronic immunosuppressants * Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Pregnant or breast-feeding * History of a different malignancy unless disease-free for at least 5 years and deemed by the investigator to be at low risk for recurrence. * HIV-positive individuals on combination antiretroviral therapy