The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
12
University of Essex
Colchester, Essex, United Kingdom
Change in flow mediated dilation
Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery.
Time frame: Change from baseline at 15 minutes after ischemia-reperfusion injury
Change in low flow mediated constriction
low flow mediated constriction is a measure of vascular function and is measured to establish the impact of a vascular injury
Time frame: Change from baseline at 15 minutes after ischemia-reperfusion injury
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