The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.
Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable), and intravenous forms of beta-lactam antibiotics . Diagnostic values of the measurement of specific Immunoglobulin E to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents. The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.
Study Type
OBSERVATIONAL
Enrollment
500
Chulalongkorn University
Bangkok, Thailand
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity
The skin test positive rate in patients with a history of beta-lactam hypersensitivity
Time frame: 1 year
Clinical values of various diagnostic modalities in patients with a history of beta-lactam hypersensitivity
The diagnostic values of skin testing, drug-specific Immunoglobulin E measurement, and interferon-gamma ELISpot assay for the diagnosis of beta-lactam hypersensitivity
Time frame: 1 year
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