Aizthromycin or Clarithromycin in H-pylori Eradication Regimen

Shahid Sadoughi University of Medical Sciences and Health Services78 enrolled

Overview

The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries. There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs. The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Peptic Ulcer Dyspepsia H-pylori

Interventions

azithromycinDRUG

Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics.\[1\] It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered.

clarithmycinDRUG

Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with peptic ulcer due to H-pylori confirmed endoscopy and biopsy Exclusion Criteria: * patients who got H-pylori eradication treatment previously * patients who used study drugs during 3months before study

Locations (1)

Behnam Baghianimoghadam

Yazd, Yazd Province, Iran

Outcomes

Primary Outcomes

H-pylori cinfirmation

confirmation is by endoscopy and biopsy

Time frame: 1-3 months before study

Secondary Outcomes

h-pylori eradication confirmation

confirmation of eradication was by endoscopy and biopsy

Time frame: two months after completion of 14 days standard treatment

side effect of study srugs

it was assessed by researcher and self report of patients. variables like nausea, vomiting and diarrhea. the prevalence of each treatment related complain was registered by taking history from patients.

Time frame: during 14 days standard treatment

Data from ClinicalTrials.gov

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