Photodynamic Therapy in Treating Patients With Lung Cancer

Inclusion Criteria: * Patients with biopsy confirmed carcinoma-in-situ (CIS) or microinvasive lung cancer * Patients may have squamous cell carcinoma, adenocarcinoma, or large cell carcinoma * Patients may have received prior therapy for lung cancer of any type, e.g. chemotherapy, radiation therapy * Patients must have no contraindications for bronchoscopy * Female patients must not be pregnant and must be practicing a medically acceptable form of birth control, be sterile or post-menopausal * Patients must have a Karnofsky scale 50 or above (Eastern Cooperative Oncology Group \[ECOG\] 0-2) * Patients must sign an Informed Consent according to Food and Drug Administration (FDA) guidelines acceptable to the Roswell Park Cancer Institute (RPCI) Institutional Review Board (IRB) * Patients with underlying lung disease must be judged (by the principal investigator) able to with stand mucous/debris formation at the site of treatment * Definition of CIS or microinvasive lung cancer for this protocol: the lesion will be radiographically occult and not definable by conventional computed tomography (CT) of the chest; the lesion may or may not be invisible on white light bronchoscopy, but is definable and photographable on lung imaging fluorescence endoscope (LIFE) bronchoscopy; biopsies of the lesion must indicate no evidence of invasion beyond cartilage on histopathology; the lesion may, however, be invasive through the basement membrane (microinvasive carcinoma) Exclusion Criteria: * Porphyria or hypersensitivity to porphyrin or porphyrin-like compounds * White blood cells (WBC) \< 4000 * Platelet count \< 100,000 * Prothrombin time exceeding 1.5 times the upper normal limit * Total serum bilirubin \> 3.0 mg/dl * Serum creatinine \> 3.0 mg/dl * Alkaline phosphatase (hepatic) or serum glutamic oxaloacetic transaminase (SGOT) \> 3 times the upper normal limit * Severe chronic obstructive pulmonary disease (COPD) that would in the opinion of the investigator preclude multiple bronchoscopies or partial central airway obstruction from mucous/debris formation * Any evidence of worsening pulmonary symptoms or COPD exacerbation * Evidence of major pulmonary vessel encasement on CT scan of the chest * Myocardial infarction (Ml) or unstable angina in the previous 6 months