Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer

Inclusion Criteria: * Patients must have definitive diagnosis of head and neck cancer. * Concurrent chemoradiation treatment of the primary tumor must be an option for the newly diagnosed cancer. * Patients must be informed of the investigational nature of this study and sign and give written informed consent in accordance with institutional and federal guidelines. * Absence of life limiting medical conditions * Ability to understand and willingness to sign a written informed consent document. * ECOG performance status 0, 1, or 2 (Karnofsky \> 60%). * Patients must have adequate bone marrow function. ANC \> 1000/microL and Platelet count \>100,000/microL * Age \>20 years Exclusion Criteria: * Known familial head and neck cancer syndrome * Pregnancy * Known HIV * Patients receiving immunosuppressive drugs * Inflammatory bowel disease * Active second malignancy in the last 5 years * Patients receiving any other investigational agent(s) * Patients who have received any prior chemotherapy or radiation therapy to the primary head and neck cancer