Progranulin and CTRP3 in Metabolic Syndrome

Korea University127 enrolled

Overview

Inflammation has been known to be a pivotal pathogenic mechanism of obesity-related disorders such as type 2 diabetes, metabolic syndrome and atherosclerosis. Adipose tissue functions as a major endocrine organ by adipokine mediated modulation of a number of signaling cascades in target tissues, that has pro-inflammatory or anti-inflammatory activities. Progranulin and CTRP3 are recently discovered novel adipokines. Therefore, the investigators tried to clarify the clinical meaning of these two adipokines in the subjects with or without metabolic syndrome

Study Type

OBSERVATIONAL

Enrollment

127

Conditions

Metabolic Syndrome

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 20\<age\<80 * apparently healthy subjects Exclusion Criteria: * a history of CVD * diabetes * stage 2 hypertension * malignancy * severe renal or hepatic disease

Locations (1)

Korea University Guro Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Serum concentration of progranulin in the subjects with metabolic syndrome

Time frame: 12week

Serum concentration of CTRP3 in the subjects with metabolic syndrome

Time frame: 12week

Secondary Outcomes

The relationship of serum progranulin levels with cardiovascular risk factors

Time frame: 12 week

The relationship of serum CTRP3 levels with cardiovascular risk factors

Time frame: 12 week

Data from ClinicalTrials.gov

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