Empirical Rescue Therapies of Helicobacter Pylori Infection

Shanghai Jiao Tong University School of Medicine424 enrolled

Overview

The increase of antibiotic resistance to H. pylori causes failure of treatment. Furazolidone, amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these three antimicrobials was rare. It is necessary to assess the efficacy and safety of these four bismuth-containing quadruple regimens with above antibiotics as empirical rescue therapies for H. pylori eradication.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

424

Conditions

Functional Dyspepsia Scarred Peptic Ulcer

Interventions

Proton Pump InhibitorDRUG

BismuthDRUG

MetronidazoleDRUG

TetracyclineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * H. pylori -positive patients with functional dyspepsia and scarred peptic ulcers who had previously failed one or more eradication regimens containing clarithromycin, metronidazole and/or amoxicillin. Exclusion Criteria: * less than 18 years old, never receiving eradication treatment before, with previous gastric surgery, pregnancy, lactation, major systemic diseases, administration of antibiotics, bismuth, antisecretory drugs in the preceding 8 weeks

Locations (1)

Renji Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

eradication rate of H. pylori

Time frame: 2 months

Data from ClinicalTrials.gov

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