Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke

MicroTransponder Inc.21 enrolled

Overview

Patients (UK only) at least 6 months post stroke, with upper limb deficits, may enroll. Patients will be randomized to one of two groups - a group implanted with a device that allows pairing VNS with rehabilitation and a group that only receives rehabilitation (no implant). Patients have two baseline evaluations, one evaluation after implant but before initiation of treatment, and then six weeks of rehabilitation or rehabilitation + VNS, followed by post acute therapy evaluations at 1, 7, and 30 days after the 6-weeks of treatment. The intent is to assess safety and provide preliminary effectiveness information for VNS for upper limb functional improvement after stroke. Implanted patients may receive longer-term treatment and follow-up after the acute study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Stroke

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Major Inclusion Criteria: 1. History of unilateral supratentorial ischemic stroke that occurred at least 6 months prior 2. Age \> 18 years and \< 80 years 3. Right or left sided weakness of upper extremity Major Exclusion Criteria: 1. Hemorrhagic stroke 2. Any deficits in language or attention that interferes with reasonable study participation 3. Presence of significant apraxia 4. Profound Sensory loss 5. Active major neurological or psychiatric diagnosis that would likely interfere with study protocol including alcohol or drug abuse

Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes