Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Acute Respiratory Distress Syndrome (ARDS)

Policlinico Hospital30 enrolled

Overview

In this study gas-exchange and respiratory mechanics variations to PEEP change will be correlated to CT lung morphological modifications assessed at different airway pressures (5, 15, 30 and 45 cmH2O).

Study Type

OBSERVATIONAL

Enrollment

Conditions

ARDS: Acute Respiratory Distress Syndrome

Interventions

Chest computed tomographyRADIATION

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of acute lung injury/ acute respiratory distress syndrome * Mechanical ventilation Exclusion Criteria: * Clinical diagnosis of chronic obstructive pulmonary disease * Clinical diagnosis of pneumothorax * Haemodynamic instability

Locations (1)

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, Italy

Outcomes

Primary Outcomes

Computer Tomography (CT) scan lung recruitment and CT lung weight

Aim of the study is to determine the relationship between the opening pressures (recruitment) and closing pressures (PEEP) in order to prevent the opening and closing of the lung parenchyma

Time frame: Study day (day 1)

Data from ClinicalTrials.gov

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