Availability & Effect of Post-OP Ketorolac on Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Inclusion Criteria: (PRE-OPERATIVE \[OP\]) * Patients must be suspected of having a diagnosis of ovarian, fallopian tube or primary peritoneal cancer with a planned cytoreductive surgery * Borderline ovarian cancer with ascites * Eastern Cooperative Oncology Group (ECOG)/Zubrod/ Southwest Oncology Group (SWOG) performance status \< 2 (Karnofsky performance status \>= 70%) * Ability to provide informed consent * Absolute neutrophil count \> 1000/uL * Platelet count \> 100'000/uL * Serum creatinine =\< 1.5 x upper limit of normal (ULN) * Bilirubin =\< 1.5 x normal * Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \[AST\]) or serum glutamic pyruvic transaminase (SGPT) (alanine aminotransferase \[ALT\]) levels =\< 2 x ULN * No known bleeding disorders * No known sensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) * No active peptic ulcer disease * No active bleeding * SECONDARY ELIGIBILITY * Histologic diagnosis of epithelial ovarian, fallopian tube or primary peritoneal cancer on frozen section diagnosis * Placement of an intraperitoneal port at the time of surgery for anticipated use for adjuvant chemotherapy or management of post-operative ascites * If epidural catheter was used - the catheter must be removed prior to treatment * No active bleeding Exclusion Criteria: * Non-epithelial ovarian cancer or metastatic cancer to the ovaries * Borderline ovarian cancer without ascites * Presumed early stage ovarian cancer * No clinical indication for a peritoneal port * Active use of an epidural catheter * Uncontrolled or unstable medical conditions * Off study use of ketorolac or other NSAIDs prior to study administration * Active bleeding or high risk of bleeding * Active therapeutic anticoagulation * Known hypersensitivity to NSAIDs * Chronic or acute renal insufficiency as defined by a preoperative serum creatinine greater than 1.5mg/dL or creatinine clearance of \< 60 ml/min * Any co-morbid condition that' in the view of the attending physician' renders the patient at high risk from treatment complications