Cardiopulmonary Complication in Aneurysmal Subarachnoid Haemorrhage Patients

Kuopio University Hospital198 enrolled

Overview

This is a prospective cohort study investigating cardiac function and cardiac biomarkers in patients with acute Aneurysmal Subarachnoid Haemorrhage (aSAH). The aims of the study are to document the incidence of myocardial dysfunction,to find the predictive factors of myocardial dysfunction, describe heart rate variability and to assess the impact of all cardiac problems on morbidity and mortality.

Laboratory markers daily: Routine laboratory test (blood gases, haemoglobin, thrombocytes, leukocytes, INR, bilirubin, creatinine, c-reactive protein, CK, CK-MB, Tnt, BNP, sodium, potassium, magnesium) are taken at 8 a.m. Study laboratory tests (sensitive ischemia markers, remodelling marker MMP-9 and CgA as surrogate marker for increased sympathetic activity) are taken four times during study period at the same time as cardiac ECHOes and Holtering. Gene sample is taken once on day one. Primary outcome measurement is to document the incidence of myocardial dysfunction and the predictive factors during the hospital stay and at three months. Secondary outcome is to assess the impact of cardiac problems on morbidity and mortality during first three months.

Study Type

OBSERVATIONAL

Enrollment

198

Conditions

Aneurysmal Subarachnoid Heamorrhage Nontraumatic Subarachnoid Haemorrhage

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with nontraumatic subarachnoid haemorrhage * Age \> 18 years * Aneurysmal bleeding Exclusion Criteria: * No consent * Age \< 18 years * Anticipated brain death \< 24 hours * Otherwise moribund patient

Locations (3)

Kuopio University Hospital

Kuopio, Finland

Turku University Hospital

Turku, Finland

Inselspital Bern

Bern, Switzerland

Outcomes

Primary Outcomes

Incidence of cardiac failure and the impact of cardiac problems on morbidity

The aims of the study are: 1. to document the incidence of myocardial dysfunction 2. to find the predictive factors of myocardial dysfunction as determined by the severity aneurysmal bleeding (Hunt and Hess-grading, Glasgow coma score, Fisher scale) and demographic factors 3. to find predictive factors for myocardial dysfunction as determined by laboratory findings, electrocardiography, and echocardiography 4. to describe heart rate variability 5. to assess the impact of all cardiac problems on morbidity

Time frame: 6 months

Data from ClinicalTrials.gov

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