Sinonasal Gas Exchange Dynamics

Louisiana State University Health Sciences Center Shreveport12 enrolled

Overview

Sinonasal gas exchange is facilitated by the unique anatomy and topography of the sinonasal interface that represents a collection of airfoils creating an aerodynamic structure. The airflow during respiration generates positive and negative pressures that power the gas exchange between the sinuses and the nose. Major surgical alteration of the interface reduces the rate and velocity of the exchange. Minimally invasive procedures aimed at preserving the natural anatomy, topography and aerodynamic configuration of the interface will have negligible effects on sinonasal gas exchange.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sinusitis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Control: * normal healthy adult volunteers ages 18-65, * without allergies by history and allergy test, * non-smoker, * not using steroids. Study group 1: adult subjects who had maxillary sinus balloon sinuplasty (with intact uncinate and ethmoid complex) Study group 2: adult subjects who had endoscopic maxillary antrostomy and uncinectomy. Exclusion criteria: * active acute or chronic infection, * nasal polyps, * severe nasal or septal deformity, * cystic fibrosis, * systemic illness (diabetes, hypertension etc.), * vulnerable population (children, pregnant women, institutionalized individuals etc.) * severe nasal and/or septal deviation, * hypersensitivity or intolerance to study medications (topical and local anesthetics) any turbinate surgery.

Locations (1)

LSU Health ACC

Shreveport, Louisiana, United States

Outcomes

Primary Outcomes

Sinonasal gas exchange rate

ANALYZE AND DEFINE GAS EXCHANGE PATTERNS IN THE MAXILLARY SINUS DURING NASAL RESPIRATION IN NORMAL SINUSES AND COMPARE WITH SURGICALLY MODIFIED SUBJECTS THAT WILL INCLUDE MAXILLARY SINUSES AFTER ENDOSCOPIC SINUS SURGERY AND BALLOON SINUPLASTY.

Time frame: 2 years

Secondary Outcomes

NO production rate

ANALYZE AND DEFINE NITRIC OXIDE PRODUCTION RATE AND VARIABLES IN NORMAL AND SURGICALLY ALTERED MAXILLARY SINUSES

Time frame: 2 years

Data from ClinicalTrials.gov

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