A Phase 1b Study Assessing GS-7340 in Treatment-Naive Adults With Chronic Hepatitis B

Inclusion Criteria: * Must be between 18 and 65 years of age * Must have Screening plasma HBV DNA ≥ 2x10\^3 IU/mL * Must have chronic HBV infection for at least 6 months * Must have estimated creatinine clearance (CLCr) ≥ 70 mL/min * Not pregnant or nursing * Women must be of non-childbearing potential OR of childbearing potential with confirmed negative pregnancy tests * Consistent and correct use of recommended methods of birth control for men and women Exclusion Criteria: * Pregnant or lactating subjects * Receipt of anti-HBV nucleoside/nucleotide therapy. Subjects who have failed prior Interferon treatment, greater than 6 months prior to screening, are permitted to participate in the study screening * Known co-infection with HIV, hepatitis C virus (HCV) or hepatitis D virus (HDV) * Presence of autoimmune disorders * History of liver disease other than Hepatitis B * History of Gilbert's Disease * Any sign of decompensated liver disease * Known or suspected cirrhosis * Evidence of hepatocellular carcinoma * Presence or history of cardiovascular disease, cardiomyopathy, and/or cardiac conduction abnormalities * Electrolyte abnormalities * History of treatment that permanently alters the gastric condition * Alcohol or substance abuse * History of bleeding diathesis * Significant bone disease