Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea

Malin Jonsson Fagerlund11 enrolled

Overview

This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

OSA Rocuronium Neuromuscular Blockade Hypoxic Ventilatory Response CPAP

Interventions

RocuroniumDRUG

Partial neuromuscular blockade with rocuronium with a TOF 0.70

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male with diagnosed moderate OSA (AHI 15-30), untreated, but planned for CPAP treatment. Healthy except for OSA and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. None smokers. 18-70 years old. BMI \<35. Exclusion Criteria: * If they don´t fit the inclusion criteria

Locations (1)

Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital

Stockholm, Sweden

Outcomes

Primary Outcomes

Hypoxic ventilatory response

Time frame: At baseline, with CPAP, at TOF 0.70 and at TOF >0.90. At diagnosis and after 3 month of CPAP treatment at home

Secondary Outcomes

Hypercarbic ventilatory response

Time frame: At baseline, with CPAP, at TOF 0.70 and at TOF >0.90. At diagnosis and after 3 month of CPAP treatment at home

Hypoxic ventilatory response

Time frame: At diagnosis and after 3 month of CPAP treatment at home

Hypoxic ventilatory response during acute CPAP treatment

Time frame: At diagnosis and after 3 month of CPAP treatment

Hypercarbic ventilatory response

Time frame: At diagnosis and after 3 month of CPAP treatment at home

Hypercarbic ventilatory response during acute CPAP treatment

Time frame: At diagnosis and after 3 month CPAP treatment at home

Upper airway obstruction

Time frame: At TOF 0.70 and TOF >0.90. At diagnosis and after 3 month CPAP treatment.

Data from ClinicalTrials.gov

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