The purpose of this study is to determine whether pramipexole and bromocriptine are effective in the treatment of non-motor symptoms in Parkinson's Disease.
PRIMARY OBJECTIVE Evaluate the Improvement of Nonmotor symptom scale (NMSS) between Pramipexole and Bromocriptine for early Parkinson's disease during 24-week treatment SECONDARY OBJECTIVE * Evaluate the improvement for Depression which is one of the Nonmotor symptoms * Evaluate the improvement of clinical symptoms between two groups * Evaluate the improvement of Quality of Life between two groups
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
121
pramipexole
bromocriptine
Korea University Ansan Hospital
Ansan, South Korea
Inje University Busan Paik Hospital
Busan, South Korea
Youngnam University Hospital
Daegu, South Korea
Kangwon Nat'l University Hospital
Kangwon, South Korea
K-NMSS
Evaluate The total and each category score of K-NMSS
Time frame: 24 weeks
K-MADRS
Evaluate the Improvement of the depression refering to the total score of K-MADRS
Time frame: 24 weeks
UPDRS I/II/III
Evaluate the improvement of UPDRS I/II/III
Time frame: 24 weeks
K-PDQ39
Evaluate the improvement of Patient's QOL
Time frame: 24 weeks
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Inje university Sanggye Paik Hospital
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Korea University Anam Hospital
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Korea University Guro Hospital
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