Prucalopride Subjects With Renal Impairment

Inclusion Criteria: All subjects had to meet the following inclusion criteria: * Between the ages of 18 and 75 years, inclusive; * Males or females. Females were to be of non-childbearing potential. Normal subjects had to meet the following additional inclusion criteria: * Demographically comparable to the subjects with renal impairment, within 30% of mean weight and height and 10% of the mean age; * Physical examination, clinical laboratory results, and 12-lead ECG within normal limits at screening; * No intake of medication, including over-the-counter medication, during a pre-trial 7-day drug-free washout period; Subjects with renal impairment had to meet the following additional inclusion criteria: * Stable severity of renal disease; * Concomitant medications to treat underlying disease states or medical conditions related to renal insufficiency were allowed; * Stable dose of medication and/or treatment regimen from 2 months prior to and during the trial; * Subjects with stable cardiovascular disease could be enrolled, provided that the investigator felt their condition would not interfere with the results of the trial. Exclusion Criteria: All subjects who met any of the following criteria were excluded from the trial: * History of hypersensitivity to prucalopride or inactive ingredients in the prucalopride capsule or to related prokinetic compounds; * Use of any other investigational drug within 30 days prior to signing the consent or intention to take any investigational drug during the trial; * History of significant blood loss, or blood plasma donation (500mL) within the last 30 days; * Pregnancy or breast feeding; * Gastrointestinal (GI) surgery within 3 months, or history of major GI surgery with potential compromise of drug absorption or metabolism; Normal subjects who met any of the following criteria were excluded from the trial: * Any abnormal medical history, physical examination, ECG, or laboratory results; * Use of medications 7 days prior to and during the trial. * Subjects with renal impairment who met any of the following criteria were excluded from the trial. * Any abnormality in medical history, physical examination, ECG, or laboratory results that, in the opinion of the investigator, might affect the safety of the subject; * History of uric acid stone disease, uricosuria, or gout, or current hyperuricemia; * Renal transplants, lupus erythematosus, or renal carcinoma.