Addition of Lidocaine to Levobupivacaine Reduces Intrathecal Block Duration

Diskapi Teaching and Research Hospital40 enrolled

Overview

The main objective was to test the hypothesis that adding lidocaine to hyperbaric levobupivacaine could change the duration of levobupivacaine spinal block.

A satisfactory spinal anaesthesia requires both a fast onset and proper duration at the same time. Transurethral resection of the prostate (TUR-P) is a surgery of medium duration. The addition of lidocaine to hyperbaric bupivacaine shortens the duration of bupivacaine spinal block and therefore provides more rapid recovery. This property of lidocaine is not verified with other local anesthetics. Levobupivacaine is a S-enantiomer of racemic bupivacaine and is a long acting local anesthetic.The aim of this prospective randomized controlled study was to investigate this effect of lidocaine, with a local anesthetic other than bupivacaine. It was hypothesized that the duration of the intrathecal block could change when performed with hyperbaric levobupivacaine mixed with low dose lidocaine and this technique could be consistent for the duration of TUR-P surgery. Participants will be followed on the day of surgery for primary and secondary outcome measures and 3 days postoperatively for complications (TNS).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Benign Prostate Hyperplasia

Interventions

Levobupivacaine lidocaine spinal anesthesiaDRUG

Spinal anesthesia

levobupivacaine Spinal anesthesiaDRUG

spinal anesthesia

Eligibility

Sex: MALEMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective transurethral resection of the prostate (TUR-P) Exclusion Criteria: * patients with contraindications for spinal anesthesia, * known sensitivity to the study drugs, * emergency cases, and * patients who refused spinal anaesthesia were excluded

Locations (1)

Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital

Ankara, Turkey (Türkiye)

Outcomes

Primary Outcomes

The duration of the spinal block (S1 regression of the block)

the time between the intrathecal injection and sensorial block regression to S1 dermatome, measured in minutes

Time frame: participanta will be followed on the operation day

Secondary Outcomes

postoperative care unit stay

the time between the patient entered the PACU and left the PACU (when the sensorial block was regressed to S1 dermatome and the patient fulfilled an Aldrete score higher or equal to 9), measured in minutes

Time frame: participants will be followed on the operation day

Data from ClinicalTrials.gov

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