IGF-1, IGFBP3, ALS Normative Ranges in Healthy Pediatric Spanish Population

Inclusion Criteria: * Children of either sex of Caucasian parents * Age: newborns up to and including 18 years of age * Length/height, weight and body mass index (BMI) within the mean +/- 2SD (Standard Deviation) and in accordance with the growth charts of the 2010 Spanish cross-sectional growth study (Carrascosa Lezcano et al 2010) * Signed consent by at least one parent or legal guardian (if subject is ≤18 years) and by subject if ≥12 years Exclusion Criteria: * Early or advanced puberty (pubertal signs: between 8 and 9 years old in girls, and between 9 and 10 years old in boys), or delayed puberty (no puberty onset in ≥ 13 year-old girls, and in ≥ 14 year-old boys) * Chronic diseases including, but not limited to, endocrinologic diseases, chromosomal diseases, chronic diseases of renal, hepatic and/or cardiac aetiology, and tumour processes * An acute disease during the last two weeks prior to recruitment * Any clinically significant out-of-range lab value * Healthy paediatric volunteers who are under medical treatment (contraception permitted) * A family history of short stature (either parent \< P3) * Children born small for gestational age (birth weight, length, or head circumference \< P10) * Adopted children or conceived through in vitro fertilization ( IVF ) * Subjects who are unwilling or unable in the opinion of the investigator or sponsor to undergo all the study procedures