Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers

Tahitian Noni International, Inc.317 enrolled

Overview

The purpose of this study was to determine if noni juice reduces lipid hydroperoxide (LOOH) and malondialdehyde (MDA) derived-DNA adducts, markers of oxidative DNA damage, in peripheral blood lymphocytes of cigarette smokers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

317

Conditions

DNA Damage

Interventions

Noni juiceDIETARY_SUPPLEMENT

Ingestion of noni juice, a source of iridoids, daily for 30 days.

PlaceboDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 to 65 years in age, smoker of more than 20 cigarettes per day, a smoking history exceeding one year, and willing to complete a one month trial. Exclusion Criteria: * concurrent use, or use in the previous three months, of prescription medication or antioxidant vitamins

Locations (1)

University of Illinois College of Medicine at Rockford

Rockford, Illinois, United States

Outcomes

Primary Outcomes

LOOH and MDA-DNA adducts

LOOH and MDA-DNA adducts in lymphocytes immediately prior to intervention and at completion of intervention.

Time frame: 1 month

Secondary Outcomes

adverse events

Adverse health events

Time frame: 1 month

Data from ClinicalTrials.gov

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