This open-label, extension study is designed to provide continuing treatment with RO5045337 to participants who have completed parent studies NO21279 (NCT00623870), NO21280 (NCT00559533), NP25299 (NCT01164033), NP28021 (NCT01605526) or NP28023 (NCT01635296). Participants are eligible to participate in this study if they have completed required Phase 1 study assessments for primary objectives of respective parent protocol and are having evidence of clinical benefit (as defined by the parent protocol). Participants will continue the most similar dose and formulation available (which does not exceed the maximum tolerated dose \[MTD\] or the maximum safely administered dose for that formulation during Phase 1) and the same schedule of RO5045337 treatment that they were receiving at the time of transitioning from the parent clinical study protocol.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
11
Participants will receive RO5045337 orally in doses ranging from 20 milligram per square meter (mg/m\^2) to 1800 mg/m\^2 daily, and up to 1500 mg dose twice daily on a variety of schedules including daily for up to 20 days and weekly dosing for 3 weeks in 28 day cycles until disease progression or unacceptable toxicity with maximum treatment duration of 24 months.
Sarcoma Oncology Center
Santa Monica, California, United States
M.D Anderson Cancer Center; Oncology
Houston, Texas, United States
Cancer Therapy & Research Ctr; Dept Institute for Drug Development
San Antonio, Texas, United States
Princess Margaret Hospital, Medical Oncology & Haematology
Toronto, Ontario, Canada
Institut Claudius Regaud; Departement Oncologie Medicale
Toulouse, France
Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)
Time frame: Approximately 24 months
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