The aim of this study is to determine whether insulin glulisine is more effective in postprandial glycemic control than insulin aspart after the H-GI meal in children with type 1 diabetes (T1DM) treated with insulin pump (CSII).
Some studies have suggested that insulin glulisine (GLU) has a slightly faster onset of action compared with insulin aspart (ASP). Meals of high glycemic index (H-GI) have distinct effect on postprandial glycaemia (PPG).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
64
Department of Pediatrics, Medical University of Warsaw, Poland
Warsaw, Poland
Postprandial glycemia
Time frame: baseline, 30, 60, 90, 120 and 180 minutes after the breakfast
Hypoglycemia episodes
Hypoglycemia was defined as a PG concentration below 65 mg/dl with or without symptoms
Time frame: 3-h study period
Glucose Area Under the Curve (AUC)
based on continuous glucose monitoring system
Time frame: 3-h study period
Mean amplitude of glycemic excursion (MAGE)
Time frame: 3-h study period
Difference between the maximum and baseline glycemia
Time frame: 3-h study period
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