A PhaseⅡ Study: SOX vs SP in Adjuvant Chemotherapy After D2 Surgery

Inclusion Criteria: * histologically confirmed Phase III adenocarcinoma of gastric and esophageal-gastric junction ( AJCC 7th) * without previous treatment, including radiotherapy, chemotherapy and immunotherapy * Hb≥90g/L,WBC 4×109/L-10×109/L,ANC≥2×109/L,Platelet≥100×109/L * creatinine≤1 UNL * total bilirubin≤1.5 UNL,AST(SGOT),ALT(SGPT) and ALP≤2.5 UNL * ECOG score 0 - 2 * take chemotherapy for 8 weeks after surgery * older than 18 years * can be followed up, good compliance * can take medicine orally * having signed informed consent Exclusion Criteria: * combined disease lead to Life Expectancy less than 3 years * any evidence to show metastasis,including cancer cells in peritoneal fluid * inability to take oral medication for difficult to swallow, intestinal obstruction，active intestinal blooding or perforation * previous treatment,including cytotoxic chemotherapy, radio chemotherapy or immunotherapy ( except corticosteroid hormone） * operation within 4 weeks, or not recovered from last major operation * allergy with fluorouracil * allergy with Platinum or any composition in research drugs * uncontrollable seizure disorder，central nervous system disease or mental disorders, and has clinical significance by judgement of researchers, or can influnce understanding of informed consent or compliance to take orally drugs * in the past 12 months, has clinical significant heart disease(active),such as symptomatic coronary heart disease, \> =Stage II congestive cardiac failure;congestive heart failure as NYHA standard, or serious arrhythmias need take medicine( as Appendix 10th),or myocardical infarction. * pregnancy， lactation， women in child-bearing period and her spouses reject to take effictive method to conraception * other previous malignancy within 5 years, except healed skin basal cell carcinoma and carcinoma in cervix * peripheral neuropathy\> grade 1 of CTCAEv3, except the neural abnormality patients who only lose deep tendon reflex（DTRs）. * serious complicated infection or other complicated diseases and hard to controll. * As one of belowing: * ANC \< 2×109/L * Platelet\<100×109/L * total bilirubin\>1.5 UNL * ALAT、ASAT \> 2.5 x ULN * ALP\> 2.5 x ULN * Any investigational agent within the past 28 days. That is the patient had jioned another trial.