Fat Quality on Blood Lipids and Immune Response

University of Oslo180 enrolled

Overview

The purpose of this study is to investigate blood LDL-cholesterol and level of inflammatory markers after intake of food items with different fatty acid composition.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

180

Conditions

Dietary Prevention

Interventions

Food itemsOTHER

Food items with different fatty acid composition

Eligibility

Sex: ALLMin age: 25 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * hsCRP \< 10 mg/L * total cholesterol 5-7.8 mmol/l(50-70 y) * total cholesterol 5.0-6.9 mmol/l (30-49 y) * total cholesterol 5.0-6.1 mmol/l (25-29 y) * LDL-cholesterol at or above 3.5 mmol/l * triglycerides at or lower 2.6 mmol/l * BMI 20-35 * Stable bodyweight last 3 months. Exclusion Criteria: * Chronic diseases * fasting glucose \> 6.0 mmol/l * increased ASAT and ALAT * medications affecting lipidmetabolism and inflammation

Locations (1)

University of Oslo

Oslo, Norway

Outcomes

Primary Outcomes

Change in LDL-cholesterol

Change in LDL-cholesterol when compared to control diet

Time frame: Change from baseline after 8 weeks

Change in total cholesterol

Change in total cholesterol when compared to control diet

Time frame: Change from baseline after 8 weeks

Secondary Outcomes

Inflammatory markers in circulation and at gene expression level in PBMC

Time frame: Inflammatory markers are measured at baseline and after 8 weeks intervention in circulation and at gene expression level in PBMC

Markers of lipid metabolism at gene expression level in PBMC

Time frame: Markers of lipid metabolism at gene expression level in PBMC is measured at baseline and after 8 weeks of intervention

Appetite hormones

Time frame: Appetite hormones is measured at baseline and after 8 weeks of intervention

Gut peptides

Time frame: Gut peptides are measured at baseline and after 8 weeks of intervention

Metabolites

Targeted and untargeted metabolomics will be measured

Time frame: Metabolites are measured at baseline and after 8 weeks of intervention

Whole genome gene expression

Microarray

Time frame: whole genome gene expression profiles are measured at baseline and after 8 weeks of intervention

Data from ClinicalTrials.gov

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