Dose Escalation Study to Investigate Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BAY85-3934 in Subjects With Chronic Kidney Disease (CKD)

Inclusion Criteria: * Presence of chronic kidney disease (CKD) not on dialysis assessed by medical history and eGFR (MDRD) = \< 60 mL/min estimated at the pre-study visit * Stable renal disease, ie not expected to begin dialysis during the study * Systolic blood pressure =\>110 mmHg and =\<160 mmHg * Heart rate =\<100 BPM * Hemoglobin = \>9 g/dL * Female subjects without child-bearing potential, ie postmenopausal women with 12 months of spontaneous amenorrhea or with 6 months of spontaneous amenorrhea and serum FSH levels \>30 mIU/mL, women with 6 weeks post bilateral ovariectomy, women with bilateral tubal ligation, and women with hysterectomy * Body mass index (BMI): = \>18 and = \< 35 kg/m2 at the pre-study visit Exclusion Criteria: * Incompletely cured pre-existing diseases for which a relevant impairment of absorption, distribution, metabolism, elimination or effects of the study drug is assumed * Known hypersensitivity to the study drugs (active substances or excipients of the preparations) * Known severe allergies, non-allergic drug reactions, or multiple drug allergies * Chronic heart failure, New York Heart Association (NYHA) III-IV * Coronary artery disease with uncured significant stenosis * Angina pectoris * Significant stenosis of cerebral vessels * Significant uncorrected rhythm or conduction disturbances such as a second- or third-degree atrioventricular block without a cardiac pacemaker or episodes of sustained ventricular tachycardia * Subjects with impaired liver function (Child Pugh B to C based on medical history) * History of thrombotic or thromboembolic events (eg myocardial infarction, stroke, transient ischemic attack, deep vein thrombosis, pulmonary embolism) within the recent 6 months * Proliferative choroidal or retinal disease, such as neovascular age-related macular degeneration or proliferative diabetic retinopathy that required or is likely to require treatment (intraocular injections or laser photocoagulation) during the study * Subjects with a history of malignant disease during the last 5 years * Treatment with EPO-stimulating agents (ESA) or rhEPO within the last 2 weeks before first intake of study drug * Suspicion of drug or alcohol abuse * Positive results for hepatitis B virus surface antigen (HBsAg), hepatitis C virus antibodies (anti-HCV), human immune deficiency virus antibodies (anti-HIV 1+2) at the pre-study visit