This study will evaluate the effect of LCZ696 and valsartan on natriuresis, diuresis, and blood pressure in salt-sensitive Asian hypertensive patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
72
Novartis Investigative Site
Anaheim, California, United States
Novartis Investigative Site
Cypress, California, United States
Novartis Investigative Site
Cumulative Sodium Excretion (Natriuresis) at Day 1
Urine will be collected in fractions of 6 to 24 hours post-dose. From each fraction, a sample will be drawn for analysis of sodium Day 1
Time frame: 0-6 and 0-24 hours on Day 1
Cumulative Sodium Excretion (Natriuresis) at Day 28
Urine will be collected in fractions of 6 to 24 hours post-dose. From each fraction, a sample will be drawn for analysis of sodium Day 28
Time frame: 0-6 and 0-24 hours on Day 28
Urine Volume (Diuresis) Over Time
Urine will be collected and volume measured in fractions of 0 to 6 hours and 0 to 24 hours Day-1, Day 1 and Day 28
Time frame: Day -1, Day 1 & Day 28
Seated Office Blood Pressure (BP) (Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP)) Over Time
Seated Office BP (systolic blood pressure (SBP) and diastolic blood pressure (DBP))measurements will be performed at trough(immediately prior to dosing at the clinic). Arterial BP readings will be made with an automated BP device.
Time frame: Day-1, Day 14 and Day 28
Mean Sitting Pulse Pressure (PP) Over Time
Sitting mean pulse pressure rate was calculated between ambulatory SBP and DBP measurements
Time frame: Day-1, Day 14 and Day 28
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Glendale, California, United States
Novartis Investigative Site
Hong Kong, Shatin, NT, Hong Kong
Novartis Investigative Site
Singapore, Singapore, Singapore
Novartis Investigative Site
Singapore, Singapore, Singapore
Novartis Investigative Site
Bucheon-si, Gyeonggi-do, South Korea
Novartis Investigative Site
Koyang-si, Gyeonggi-do, South Korea
Novartis Investigative Site
Seoul, Korea, South Korea
Novartis Investigative Site
Seoul, South Korea
...and 5 more locations