The investigators want to find new challenge test for Acetylsalicylic hypersensitivity / Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient as the already established protocols in terms of sensitivity and specificity.
Hypersensitivity to Acetylsalicylic Acid or Aspirin (and other NSAIDS) is a condition that affects up to 2,5% of the population. Most cases are seen in a complex of such hypersensitivity with chronic eosinophilic rhinosinusitis with nasal polyposis and asthma. Despite research in finding a reliable in-vitro-test for the condition, challenge tests are still considered gold standard. So far oral, nasal, inhalation and intravenous routes of administration has been described in literature.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
50
1-2 drops
1 drop
Akershus University Hospital
Lørenskog, Akershus, Norway
Stavanger University Hospital
Stavanger, Rogaland, Norway
Inspiratory nasal flow measured by Rhinomanometry
Bilateral flow reduction \>40% considered positive test.
Time frame: Within 45 min from challenge
Expiratory nasal flow measured by Rhinomanometry
Bilateral expiratory flow reduction \>40% considered positive.
Time frame: Within 45 min from challenge
Pulmonary forced expiratory volume in 1 second (FEV1)
Reduction in FEV1 \>20% is considered as positive test.
Time frame: Within 45 min from challenge
Conjunctival symptoms
0=no symptoms, 1=limited redness and / or itching, 2=conjunctival redness and /or itching / swelling or bullae within 5 minutes from testing. Value 1 and 2 is considered positive if unilateral.
Time frame: Within 45 days from challenge
Nasal symptoms
Rhinorrhea, congestion and sneezing is considered as positive test.
Time frame: Within 45 minutes from challenge
Bronchial and laryngeal symptoms
Bronchospasm. tight chest, wheezing or laryngospasm is considered as positive test.
Time frame: Within 45 minutes from challenge
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