An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients

Austin Health104 enrolled

Overview

We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery

1. The investigators will study patients after cardiac surgery 2. The investigators will collect data on standard care in pre-intervention population 3. The investigators will collect demographic and clinical data 4. The investigators will collect biochemical data in the first 24 hours after surgery 5. The investigators will collect biochemical, physiological and clinical outcome data 6. The investigators will compare the standard care and intervention period data

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

104

Conditions

Cardiac Surgery

Interventions

IV fluid according to PPVOTHER

intravenous fluids

fluids according to standard careOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. immediately after ICU admission after cardiac surgery 2. mandatory mechanical ventilation - Exclusion Criteria: 1. Pressure support ventilation 2. ECMO 3. Intra-aortic balloon counterpulsation

Locations (1)

Austin Hospital

Melbourne, Victoria, Australia

Outcomes

Primary Outcomes

Mean amount of fluid given in the first 24 hours after surgery

all intravenous fluid administered

Time frame: 24 hours

Secondary Outcomes

Physiological outcome

Blood lactate

Time frame: 24 hours

Data from ClinicalTrials.gov

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