Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

Northumbria University10 enrolled

Overview

The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.

Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Nutritional and Metabolic Diseases

Interventions

CalciumDIETARY_SUPPLEMENT

Milk-calcium supplement

Eligibility

Sex: MALEHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * recreationally active * male Exclusion Criteria: * food intolerances/allergies

Locations (1)

Northumbria University

Newcastle upon Tyne, Tyne on Wear, United Kingdom

Outcomes

Primary Outcomes

Subjective appetite ratings

Subjective ratings of appetite assessed by visual analogue scales.

Time frame: 3 hour

Secondary Outcomes

Serum insulin concentration

2 hour area under the curve for serum insulin following breakfast consumption

Time frame: 2 hour

Plasma glucose-dependent insulinotropic peptide concentration

2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption

Time frame: 2 hour

Plasma glucagon-like peptide-1 concentration

2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption

Time frame: 2 hour

Data from ClinicalTrials.gov

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