Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)

Sequenom, Inc.45 enrolled

Overview

Subjects with wet AMD, dry AMD, and age-matched controls will undergo routine occular measurements, will provide a blood and cheek cell sample, and will have macular pigment optical density (MPOD) measured to determine if there is an association between genetics, MPOD and the risk of progression to wet AMD.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Eligibility

Sex: ALLMin age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * subject is diagnosed with either CNV, dry AMD or is an age-matched control * self reported as non-Hispanic Caucasian * 60 years of age or older * provides signed and dated informed consent * agrees to provide 10 mL of whole blood and two buccal swabs Exclusion Criteria: * previous donation under this protocol

Locations (1)

Morris Eye Group

Encinitas, California, United States

Outcomes

Primary Outcomes

Association between a genetic variant in the CFH gene and risk of progression to CNV

DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate a genetic variant in the CFH gene and its association with risk of progression to CNV

Time frame: Baseline

Secondary Outcomes

Genetic correlation between MPOD and risk of progression to CNV

DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate the correlation between genetics, MPOD, and risk of progression to CNV

Time frame: baseline

Data from ClinicalTrials.gov

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