To compare and evaluate the efficacy and safety of Candemore tab. versus Atacand tab. on blood pressure in patients with hypertension diagnosed congestive heart failure
This is an open label, randomized, active drug comparative, Parallel group, Multi-center, phase IV study. Patients receive candemore tablet or atacand tablet. Initial dose is 4mg/day or 8mg/day. Every 2 weeks, patients take double dose if patients blood pressure is measured SBP ≥ 100mmHg and DBP \> 60mmHg. Maximum dose is 16mg/day.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
169
* Initial dose : 4mg/day if SBP\<140mmHg and/or DBP\<90mmHg, 8mg/day if SBP≥140mmHg and DBP≥90mmHg * dose escalation : double dose if SBP≥100mmHg and DBP\>60mmHg (maximum dose 16mg/day)
* Initial dose : 4mg/day if SBP\<140mmHg and/or DBP\<90mmHg, 8mg/day if SBP≥140mmHg and DBP≥90mmHg * dose escalation : double dose if SBP≥100mmHg and DBP\>60mmHg (maximum dose 16mg/day)
Inje university pusan hospital
Busan, Busanjin-gu Gaegum-dong, South Korea
Gyeongsang national university hospital
Jinju, Chiram-dong, South Korea
Mean sitting Systolic Blood Pressure
Time frame: After 12 weeks of treatment
Mean Sitting Diastolic Blood Pressure
Time frame: After 12 weeks of treatment
echocardiography
Left Ventricle Volume, Left Ventricle Ejection Fraction, E/E' ration, Peak TR velocity
Time frame: After 12 weeks of treatment
Blood Creatinine and Potssium level
Time frame: After 4 and 12 weeks of treatment
NYHA class
Time frame: After 12 weeks of treatment
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